Trisodium citrate induced protein precipitation in haemodialysis catheters might cause pulmonary embolism
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چکیده
منابع مشابه
Trisodium citrate induced protein precipitation in haemodialysis catheters might cause pulmonary embolism.
BACKGROUND The locking anticoagulant plays a decisive role in the patency of central venous catheters (CVCs) used for haemodialysis. During injection, the hydraulic effects inevitably cause lock solution to spill into the systemic circulation. Density differences between whole blood (WB) and the lock solution cause further gravity-induced seepage of lock solution. This is followed by an influx ...
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BACKGROUND Formation of an intraluminal microbial biofilm is noted to play a significant role in the development of catheter-related infections (CRIs). Recently, it has been demonstrated that trisodium citrate (TSC) has superior antimicrobial effects over heparin for catheter locking. In this randomized controlled trial, we compared the influence of catheter locking with heparin and TSC on the ...
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BACKGROUND Central venous catheters (CVCs) continue to be used at a high rate for dialysis access and are frequently complicated by thrombus-related malfunction. Prophylactic locking with an anticoagulant, such as heparin, has become standard practice despite its associated risks. Trisodium citrate (citrate) 4% is an alternative catheter locking anticoagulant. METHODS The objective was to pro...
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The crystal structure of anhydrous tris-odium citrate, Na3(C6H5O7), has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional theory (DFT). There are two independent five-coordinate Na(+) and one six-coordinate Na(+) cations in the asymmetric unit. The [NaO5] and [NaO6] polyhedra share edges and corners to form a three-dimensional framew...
متن کاملEstimation of trisodium citrate (Citra-Lock) remaining in central venous catheters after the interdialytic interval.
Infection of central venous catheters used for haemodialysis remains an important cause of morbidity and mortality [1]. Patency of the catheters can be maintained between dialyses by a heparin lock, but this has no antibacterial activity. Sodium citrate, especially at higher concentrations, is an anticoagulant with intrinsic antibacterial activity [2]. However, citrate inadvertently entering th...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2012
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfs048